Since I'm not a programmer, this is totally incomprehensive for me but this link:http://www.amd.com/us-en/assets/content_type/white_papers_and_tech_docs/25112.PDFis AMD's official optimization guide for the Athlon64 family.If you don't allready use it, perhaps some gains could be found for the many AMD users?I have no idea if its easy or not to implement the things written in this document, but it would be interresting to see what an application that was specifically optimized for the Athlon64 architecture could gain in performance.